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pentobarbital will lower the level or influence of colchicine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital will lower the level or influence of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Loss of, or lowered response to tofacitinib may well occur when coadmi